STEM CELL REJUVENATION – HOW STEM CELLS HELP THE BODY

STEM CELLS AND SKIN HEALTH

The subcutaneous injections of Stem Cells have been shown to be effective in skin health.
Specifically, research (1) (2) has shown that:

  • Stem Cells inhibit the production of AGEs. AGEs are Advanced Glycation End products, which occur when excess glucose (sugar) attaches to proteins in the body, advancing the aging process in tissues, including skin.

  • Stem Cells significantly increase the level of a potent antioxidant in your body called superoxide dismutases (SOD), protecting cells against damage caused by free radicals (ROSs).

  • Stem Cells decrease the expression a marker called malondialdehyde (MDA), which causes toxic stress in cells, leading to senescence or death.

  • Stem Cells increase dermal thickness and collagen content of the skin and as a result the restoration of the functional capacity of skin.

  • Stem Cells improve significantly the blood supply of the skin due to angiogenesis (new blood vessel growth) through increasing the expression level of a helpful protein called vascular endothelial growth factor (VEGF).

  • Stem Cells significantly reduce wrinkles induced by UVB irradiation.

 

STEM CELLS AND OSTEOPOROSIS

Osteoporosis is one of the most common age-related diseases for both men and women. Ongoing research (6) – (9) has shown that:

  • Stem Cells possess the ability to differentiate into osteoblasts (the cells responsible for bone formation), deposit mineralized extracellular matrix, and enhance bone repair.

  • Stem Cells lead to significant improvement of trabecular bone quality, increase mineral density of the bone and therefore reduce the predisposition to fractures.

 

STEM CELLS AND CARDIOVASCULAR DISEASE (ATHEROSCLEROSIS)

Another common age-related disease is atherosclerosis or hardening of the arteries. We understand that the majority of the cause of this process is inflammation in the lining of the blood vessels (the endothelium) and oxidation caused by increased free radicals from a lack of antioxidant activity in the body. Stem Cell research (10) – (12) has shown that:

  • Stem Cells restore damaged endothelium and significantly improve the endothelial function.

  • Stem Cells reverse the adverse effects of “oxidized” LDL on endothelial cells

  • Stem Cells restore endothelial nitric oxide (NO) production, which is associated with improved cardiovascular functioning, lowered blood pressure, and improved erectile function.

  • Stem Cells can decrease atherosclerotic plaque formation.

 

STEM CELLS AND FRAILTY (SYNDROME OF AGING)

One of the related conditions to the process of aging is frailty. Frailty is defined as a clinical state of increased vulnerability resulting from aging-associated decline. Technically, a diagnosis of flty is given if a patient meets three out of five energy criteria including low grip strength, low energy, slowed walking speed, low physical activity, and/or unintentional weight loss.

Stem cell depletion is a key mechanism postulated to contribute to frailty. (13) – (15) Stem Cells can target two pathways implicated in aging frailty—inflammation and stem cell depletion.

An ongoing phase II, randomized double-blind placebo-controlled study at the University of Miami has clearly shown an improvement of the frailty syndrome, using Mesenchymal Cord Blood Stem Cells via IV (Intravenous) delivery. You can read the study HERE.

This study, called the CRATUS study, is one of the best of its kind and is beginning to show how incredibly safe and effective stem cell rejuvenation can be.

 

STEM CELLS AND NEUROLOGICAL DISORDERS

One of the most common age-related neurological disorder is Alzheimer’s Disease, Early Onset Dementia, and Age-Related Cognitive Decline (ARCD). This decline is associated with increased free radical damage, among other things. Research (16) has demonstrated that:

  • Stem Cells have shown to decrease the amyloid-β (Aβ) plaque deposits, which are direc

  • Stem Cells have been shown to increase the expression of synaptic protein markers associated with improved brain function.

  • Frequently associated with the brain damage that occurs with Alzheimer’s Disease.

 

STEM CELLS AND AUTOIMMUNE DISORDERS

  • One of the most prevalent reasons for practically all diseases is due to an imbalance in the immune system. There are many studies, in both human and rat models, where stem cells have been helpful. One particular large review study (17) outlined the benefits of stem cell administration in autoimmunity, including:

  • Stem Cells balance specific immune cells such as inhibiting the proliferation and activation of B and T lymphocytes.

  • Stem Cells, when exposed to a pro-inflammatory stimulus, secrete molecules that modulate the immune response.

 

  • EXOSOMES

  • One of the important components in regenerative medicine is using the cellular product called Exosomes. Exosomes are small vesicles in the body that transfer DNA, RNA and important immune proteins thereby altering the function of the target cells. Exosomes mediate cell-to-cell communication, and are involved in many processes including immune signaling, cell growth, tissue regeneration, and the stress response. Exosomes can travel anywhere in the body and even cross the blood brain barrier.

  • What are the advantages of exosome rejuvenation?

  • There are many reasons:

  • Can be used for local and systemic applications

  • Ability to cross the Blood-Brain-Barrier (BBB)

  • Easy controlled dosage

  • No chance of genetic mutations or Cancer-linked mutation

  • No risk of clumping

  • Fresh source-No risk of culturing and contamination

  • No risk of negative immune reactions

  • Therapeutically, one of the main reasons to use Exosomes is improving the CELL SIGNALING to Stem Cells.

  • Stem Cells work better if there is something present to communicate with it. Exosomes properly communicate with Stem Cells to improve their function.

  • DISCLAIMER: EXOSOMES should NOT be used with patients that have cancer, have , myeloproliferative disease, or primary pulmonary hypertension.suspicion of a tumor, macular degeneration with neovascularization, acute bacterial infections, recent dental surgeries, sickle cell disease, bone marrow dysplastica

Supporting articles:

  1. Leyendecker A, Pinheiro CCG, Amano MT, Bueno DF. The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for the in v

  2. Bali P, Lahiri DK, Banik A, Nehru B, Anand A. Potential for Stem Cells Therapy in Alzheimer’s Disease: Do Neurotrophic Factors Play Critical Role?. Curr Alzheimer Res. 2017;14(2):208-220.

  3. Stolzing A, Jones E, McGonagle D, Scutt A. Age-related changes in human bone marrowderived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 2008;129:163–173. doi:10.1016/j. 35. mad.2007.12.002

  4. Sethe S, Scutt A, Stolzing A. Aging of mesenchymal stem cells. Ageing Res Rev.2006;5:91– 116. doi:10.1016/j.arr.2005.10.001 34.

  5. Peffers MJ, Collins J, Loughlin J, Proctor C, Clegg PD. A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells. Stem Cell Res Ther. 2016;7:133. doi:10.1186/ 33. s13287-016-0384-2

  6. Lesions via Restoring Endothelial Function. Stem Cells Transl Med. 2015;4(1):44-55.

  7. Morawietz H., Duerrschmidt N., Niemann B. et al. Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells. Biochem Biophys Res Commun 2001; 284:961– 965.

  8. Luscher T.F., Barton M. Biology of the endothelium. Clin Cardiol 1997;20(suppl 2):II-3–II-10

  9. Antebi B, Pelled G, Gazit D. Stem cell therapy for osteoporosis.CurrOsteoporos Rep. 2014;12(1):41-7.

  10. Mirsaidi A., Genelin K., Vetsch J.R. Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis.Biomaterials. 2014 Aug;35(26):7326-35.

  11. Hicok K.C., Du Laney T.V., Zhou Y.S. et al. Human adipose derived adult stem cells produce osteoid in vivo. Tissue Eng. 2004;10:371-80.

  12. Gimble J., Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 2003;5:362-9.

  13. Bahk J.Y., Jung J.H., Han H. et al. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. ExpClin Transplant. 2010 Jun;8(2):150-60.

  14. Qiu X., Lin H., Wang Y. et al. Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats.J Sex Med. 2011 Feb;8(2):427-36. doi: 10.1111/j.1743-6109.2010.02118.x. Epub 2010 Nov 22.

  15. Qiu X., Villalta J., Ferretti L. et al. Effects of intravenous injection of adipose-derived stemcells in a rat model of radiation therapy-induced erectile dysfunction. J Sex Med 2012;9:1834-41.

  16. Kim W.S., Park B.S., Park S.H. et al. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009;53(2):96-102. doi: 10.1016/j.jdermsci.2008.08.007. Epub 2008 Oct 1.

  17. Zhang S., Dong Z., Peng Z. et al. Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose. LoS One. 2014;9(5):e97573. doi: 10.1371/journal.pone.0097573. eCollection 2014.

  18. ivo Treatment of Immune-Related Diseases: A Systematic Review. Front Immunol. 2018;9:2056. Published 2018 Sep 11. doi:10.3389/fimmu.2018.02056

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